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Contact us help shopping cart home about us   article title, keywords or abstract article title publication title author advanced search subject publisher publication browse by: home >> current clinical pharmacology, volume 3, number 1 diagnosis and treatment of paraneoplastic neurological syndromes authors: vitaliani, roberta; zoccarato, marco; giometto, bruno source: current clinical pharmacology, volume 3, number 1, january 2008 , pp. viagra over the counter usa 46-50(5) publisher: bentham science publishers < previous article | view table of contents | next article >  buy & download fulltext article: or pressing the buy now button more than once may result in multiple purchases price: $62. viagra pills available in india 97 plus tax (refund policy)         abstract: paraneoplastic neurological syndromes (pns) are remote effects of cancer that may involve any part of the nervous system. Rarity hinders their diagnosis and management and at least 60% of cases do not present a tumor at neurological symptoms onset. An important diagnostic element is detection, in patients' serum or cerebrospinal fluid, of onconeuronal antibodies which recognize antigens expressed by the nervous system and by neoplastic cells during dedifferentiation. precio viagra 10 mg bucodispersable Their detection also implies that pns have autoimmune origin and that immunomodulation could be an effective treatment. viagra eli lilly and company The lack of clinical trials due to the rarity of pns makes it hard to test the efficacy of immunomodulatory therapy, but dividing the diseases into two groups permits preliminary analysis. cheap viagra online A humoral immunoresponse prevails in group one and antibodies seem to have a pathogenetic role, indicating antibody removal strategies. Group two are mainly pns of the central nervous system with autoantibodies directed against intracellular antigens, probably involving a cell-mediated mechanism. generic viagra without prescription Immunotherapy with steroids or cytotoxic immunosuppressive agents may be useful here. viagra canada Immunomodulatory treatment is always indicated when a tumor is not found but neurological symptoms are progressing, since first line treatment is tumor identification and, where possible, removal. Keywords: paraneoplastic neurological syndromes; autoimmunity; anti-neuronal antibodies; tumor; therapy document type: research article doi: publication date: 2008-01-01 more about this publication? Current clinical pharmacology publishes frontier reviews on all the latest advances in clinical pharmacology. viagra without a doctor prescription The journal's aim i. viagra cost
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